Species = the *inability* to interbreed, or the *practice* of not interbreeding, which over millennia leads to the inability. Lions and tigers are obviously still capable of breeding, but in the wild their ranges do not overlap so it never happens. Wolves and coyotes and domestic dogs, domestic cats and Bobcats, zebras and donkeys, Bulls and yaks, bison and cows, sheep and goats, grizzly bears and polar bears, Asian elephants and African elephants, and lots of bird species all have produced offspring.
Fecundity of the resultant spawn varies.